Adverse Drug Reactions

Antibiotics account for almost half of all ED visits for adverse drug events that result from systemic medication. (Lovegrove MC et al. US Emergency Department Visits for Adverse Drug Events From Antibiotics in Children, 2011–2015. J Pediatric Infect Dis Soc. 2018 Aug 23.)
The frequency of adverse drug reactions related to trimethoprim-sulfamethoxazole in children has increased from 2000 to 2009, coincident with the increase in prescribing this drug for skin and soft tissue infections (Goldman JL, Jackson MA, Herigon JC, Hersh AL, Shapiro DJ, Leeder JS. Trends in adverse reactions to trimethoprim-sulfamethoxazole. Pediatrics. 2013 Jan;131(1):e103-8.)8
For every 14 children treated with an antibiotic for acute otitis media, one will experience an adverse drug reaction (e.g., vomiting, diarrhea, rash). (Venenkamp RP et al. Antibiotics for acute otitis media in children. Cochrane Database Syst Rev. 2015 Jun23;(6):CD000219.)

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