University of Texas Southwestern Medical Center/Children’s Medical Center Dallas

TRAINING PROGRAM DIRECTOR/CHIEF OF INFECTIOUS DISEASES: Jeffrey S. Kahn., MD, PhD
RESEARCH INTERESTS: Epidemiology and clinical features of newly emerging  human pathogens. Molecular characterization of respiratory syncytial virus.

TRAINING PROGRAM CO-DIRECTOR: Michael Serbert, MD
RESEARCH INTEREST: Pathogenesis and genetics of Streptococcus pneumonia; Health care epidemiology and infection prevention and control

ASSOCIATES/DIVISION MEMBERS:

• Samuel Davila, MD
  Research Interest:  Host response in severe sepsis
• Amanda Evans, MD
  Research Interest: Pediatric HIV; Infectious Diseases education
• Michelle Gill, MD, PhD
  Research Interest: Immunobiology of human dendritic cells and their role in the pathogenesis of clinical disease processes
• Natasha Hanners, MD
  Research Interest: Flavivirus infections, including Zika virus neurotropism; Neurovirology; Type I Interferon responses; Virus-host interactions
• Michelle, Hsiang, MD
  Research Interest: Epidemiology of malaria, strategies for elimination and eradication; global health
• Jeffrey McKinney, MD, PhD
  Research Interest: Graduate medical education, development and implementation of educational tools and resources
• Paul Sue, MD
  Research Interest: Cytomegalovirus; Hepatitis E Virus; Viral Hepatitis
• Dawn Wetzel, MD, PhD
  Research Interest: Molecular biology and pathogenesis of Leishmania

TITLE(S) OF SOME RECENT FELLOWS’ PUBLISHED PAPERS OR RESEARCH PROJECTS:

• Rowe RK, Pyle DM, Tomlinson AR, Lv T, Hu Z, Gill MA. IgE cross-linking impairs monocyte antiviral responses and inhibits influenza-driven TH1 differentiation. J Allergy Clin Immunol. 2017 Jul;140(1):294-298.e8. PubMed PMID: 28087327.
• Rowe RK, Gill MA. Effects of Allergic Sensitization on Antiviral Immunity: Allergen, Virus, and Host Cell Mechanisms. Curr Allergy Asthma Rep. 2017 Feb;17(2):9. PubMed PMID: 28233152.
• Rowe RK, Gill MA. Asthma: the interplay between viral infections and allergic diseases. Immunol Allergy Clin North Am. 2015 Feb;35(1):115-27. PubMed PMID: 25459580
• Hanners NW, Eitson JL, Usui N, Richardson RB, Wexler EM, Konopka G, Schoggins JW. Western Zika Virus in Human Fetal Neural Progenitors Persists Long Term with Partial Cytopathic and Limited Immunogenic Effects. Cell Reports. 2016 June 14; 15 (11) : 2315-22. PMID: 27268504
• Prokesch BC, TeKippe M, Kim J, Raj P, TeKippe EM, Greenberg DE. Primary osteomyelitis caused by hypervirulent Klebsiella pneumoniae. Lancet Infect Dis. 2016 Sep;16(9):e190-e195. doi: 10.1016/S1473-3099(16)30021-4. Epub 2016.

GRANT FUNDING RECEIVED FOR FELLOW RESEARCH PROJECTS:

• Rowe
• NIH T32: 5T32HL098040-07
• PIDS Fellow Award in Respiratory Virus Research, Pediatric Infectious Disease Society/Sponsored by Astra-Zeneca
• NIH Loan Repayment Program
• Hanners
• W.W. Caruth Scholar Fellow Research Award
• Tekippe
• W.W. Caruth Scholar Fellow Research Award

MAJOR FEATURES OF TRAINING PROGRAM:

The purposes of the training program are to provide a background in laboratory techniques of classical microbiology, immunology, epidemiology, and molecular biology, to provide experience in the application of the scientific method to clinical and laboratory research, to develop competence in diagnosis and management of infectious diseases and to provide expertise in infection control. Clinical training is in the form of consultations (inpatient and outpatient), rounds and conferences. The clinical material available at Children’s Medical Center (CMC) and Parkland Memorial Hospital is extensive. There are more than 300,000 outpatient visits, >15,000 pediatric admissions, and 17,000 newborns per year. The division has established collaborative research programs with the clinical and basic science investigators in many departments in The University of Texas Southwestern Medical Center and beyond including the Dallas County Department of Health and Human Service. The principal goals of these collaborative projects are to delineate the molecular and or epidemiological basis for the pathogenesis of certain infectious diseases in pediatrics.

AFFILIATED HOSPITALS:

• Children’s Medical Center Dallas
  Number of PediatricBeds: 490
• Parkland Memorial Hospital
  Number of Pediatric Beds: 100 (NICU beds)

FELLOWS ACCEPTED EACH YEAR:  2-3

TRAINING FOR MD; DO; MD, PhD: YES

FUNDING IS ENSURED FOR ALL 3 YEARS: YES

VISAS ACCEPTED: J1 only

IS COMPLETION OF PEDIATRIC RESIDENCY TRAINING IN THE U.S. OR CANADA A REQUIREMENT? NO

THE PROGRAM OFFERS THE FOLLOWING TRAINING:

Program provides training in diagnostic microbiology using laboratories on site:

• Microbiology laboratory: YES
• Clinical virus isolation laboratory: YES
• Molecular diagnostics: YES
• Other: Microbial genomics

Program provides training in infection control and hospital epidemiology as:

• Didactic lectures: YES
• Hands on experience: YES
• Infection Control Meetings/Membership: YES

Opportunity to fulfill the ABP requirements for scholarly activity is available in the following general areas:

• Bacteriology/bacterial infections: YES
• Epidemiology and statistics: YES
• Infection control/hospital epidemiology: YES
• Immunizations/Public health: YES
• Mycology/fungal infections: YES
• Parasitology/parasitic diseases: YES
• Virology/viral diseases: YES
• Antimicrobial agents: YES

Research opportunities in the section’s program could be describes as:

• Basic (bench): YES
• Molecular: YES
• Community: YES
• Epidemiologic: YES
• Clinical: YES
• International/Public Health: YES
• Health Services: YES
• HIV, Basic: YES
• HIV, Clinical: YES
• ACTG Site: NO

Documented liaison exists offering opportunities for research experience n the laboratory of investigator(s) who is (are) not faculty of the section: YES

Program offers the opportunity to obtain a Master’s degree in a field such as Public Health, Education, Clinical Sciences, or Epidemiology (assuming appropriate arrangements are made): YES

Graduate school courses are available to trainee (assuming appropriate arrangements are made): YES

Program provides substantial clinical experiences for trainees in special areas/hosts:

• HIV: YES
• Bone marrow transplantation: YES
• Solid organ/transplantation: YES
• Travelers/adoptees: YES
• Adults: YES
• Congenital immune deficiencies: YES

Program includes ABP-required core curricula in scholarly activities in didactic lecture course for fellows (includes epidemiology, statistics, research design, and academic careers): YES

Program has an NIH-sponsored training grant: NO

The Infectious Diseases Service is the primary care provider for HIV-infected children and adolescents: YES

Average number of new outpatient consultations per month: 25

Average number of established outpatient follow-up visits per month: 50

Average number of new inpatient consultations per month: 75

Number of trainees completing program in the last 5 years: 10