University of California, San Francisco / Benioff Children’s Hospital San Francisco & Oakland

TRAINING PROGRAM DIRECTOR: Manjiree Karandikar, MD, MBS

ASSOCIATE DIRECTOR/CO-DIRECTOR:  Alexander Newman, MD

COORDINATOR: Catherine Le

CHIEF,  INFECTIOUS DISEASES: Theodore Ruel, MD

MAJOR FEATURES OF TRAINING PROGRAM: Our pediatric infectious disease program is a three-year program ACGME-accredited training program. Our goal is to train leaders in the field of infectious disease. Graduates from our program have developed successful careers in clinical and basic/translational research, antimicrobial stewardship and infection control, public/global health, and education.

The first year is focused on both inpatient and outpatient clinical training at the UCSF Benioff Children’s Hospital San Francisco and Oakland campuses, including general and immunocompromised populations, including HIV/AIDS, solid organ transplant recipients, bone marrow transplant recipients, and patients with primary immunodeficiencies. In addition, we serve a large catchment area, which includes immigrant and refugee populations. In the second and third years, fellows complete clinical rotations in outpatient subspecialty clinics but devote the majority of time to research. For research mentorship, fellows have opportunities to collaborate with any of UCSF’s world-class researchers in the basic and clinical sciences.

We aim to train pediatric infectious disease providers who champion diversity, equity, and inclusion for all members of our community.

TITLE(S) OF RECENT FELLOWS’ PUBLISHED PAPERS OR RESEARCH PROJECTS:

1. Thanassi, Wendy MD, MA; Behrman, Amy J. MD; Reves, Randall MD; Russi, Mark MD, MPH; Swift, Melanie MD, MPH; Warkentin, Jon MD, MPH; Miyakawa, Ryo MD; Wegener, Donna MA; Budnick, Lawrence MD, MPH; Murray, Ellen RN, PhD; Scarpita, Ann BSN, MPH; Hurst, Bobbi Jo MBA; Foster-Chang, Sarah DNP, ANP-BC; Mathew, Trini MD, MPH; Gruden, MaryAnn MSN, COHN-S/CM; Higashi, Julie MD, PhD; Hudson, Thomas Warner III MD Tuberculosis Screening, Testing, and Treatment of US Health Care Personnel, Journal of Occupational and Environmental Medicine: July 2020 – Volume 62 – Issue 7 – p e355-e369 doi: 10.1097/JOM.0000000000001904.
2. Miyakawa R, Barreto NB, Kato RM, Neely MN, Russell CJ. Early Use of Anti-influenza Medications in Hospitalized Children With Tracheostomy. Pediatrics. 2019 Mar;143(3):e20182608. doi: 10.1542/peds.2018-2608. PMID: 30814271; PMCID: PMC6398370.
3. Wang C, Bauckman KA, Ross ASB, Symington JW, Ligon MM, Scholtes G, Kumar A, Chang HW, Twentyman J, Fashemi BE, Xavier RJ, Mysorekar IU. A non-canonical autophagy-dependent role of the ATG16L1^T300A variant in urothelial vesicular trafficking and uropathogenic Escherichia coli persistence. Autophagy. 2019 Mar;15(3):527-542. doi: 10.1080/15548627.2018.1535290. Epub 2018 Nov 8. PMID: 30335568; PMCID: PMC6351132.
4. Chu VT, Schwartz NG, Donnelly MAP, Chuey MR, Soto R, Yousaf AR, Schmitt-Matzen EN, Sleweon S, Ruffin J, Thornburg N, Harcourt JL, Tamin A, Kim G, Folster JM, Hughes LJ, Tong S, Stringer G, Albanese BA, Totten SE, Hudziec MM, Matzinger SR, Dietrich EA, Sheldon SW, Stous S, McDonald EC, Austin B, Beatty ME, Staples JE, Killerby ME, Hsu CH, Tate JE, Kirking HL, Matanock A. Comparison of Home Antigen Testing With RT-PCR and Viral Culture During the Course of SARS-CoV-2 Infection. JAMA Intern Med. 2022 Apr 29;. doi: 10.1001/jamainternmed.2022.1827. [Epub ahead of print] PubMed PMID: 35486394; PubMed Central PMCID: PMC9055515.
5. Chu VT, Simon E, Lu X, Rockwell P, Abedi GR, Gardner C, Kujawski SA, Schneider E, Gentile M, Ramsey LA, Liu R, Jones S, Janik C, Siniscalchi A, Landry ML, Christopher J, Lindstrom S, Steiner S, Thomas D, Gerber SI, Biggs HM. Outbreak of Acute Respiratory Illness Associated With Human Adenovirus Type 4 at the United States Coast Guard Academy, 2019. J Infect Dis. 2022 Jan 5;225(1):55-64. doi: 10.1093/infdis/jiab322. PubMed PMID: 34139752.

GRANT FUNDING RECEIVED FOR FELLOW RESEARCH PROJECTS:

1. T32 NIH Training Grant / Chan Zuckerberg Biohub Physician-Scientist Fellowship Program, 2022-2023
2. T32 NIH Training Grant (Clinical Pharmacology, Drug Action and Pharmacogenetics), 2021-2023
3. Clinical and Translational Science Institute TL1 Prescient Fellowship, 2020-2022
4. T32 NIH Training Grant 2019-2021
5. Pediatric Scientist Development Program Fellowship, 2018-2020
6. Clinical and Translational Science Institute TL1 Prescient Fellowship, 2017-2019
7. Thrashers Early Career Award, 2017-2019

AFFILIATED HOSPITALS:

UCSF Benioff Children’s Hospital, San Francisco: 183 beds

UCSF Benioff Children’s Hospital, Oakland: 191 beds

NUMBER OF INPATIENT/OUTPATIENT CONSULTS PER YEAR:  600

FELLOWS ACCEPTED EACH YEAR: 2

FUNDING ENSURED FOR ALL 3 YEARS: Yes

IS COMPLETION OF PEDIATRIC RESIDENCY TRAINING IN THE U.S. OR CANADA A REQUIREMENT? Yes

VISAS ACCEPTED: H1B, J1

Program provides training (didactic lectures, hands on experience, or antimicrobial stewardship meetings/membership) in:

1. Microbiology lab on site
2. Infection control and hospital epidemiology
3. Antimicrobial stewardship
4. Immunocompromised hosts

Opportunities to fulfill the ABP requirements for scholarly activity is available in the following general areas:

1. 1. Antimicrobial agents
   2. Antimicrobial stewardship
   3. Bacteriology/bacterial infections
   4. Bioethics
   5. Clinical trials
   6. Epidemiology and statistics
   7. Global health
   8. HIV
   9. Immunizations
   10. Infection control/hospital epidemiology
   11. Medical education
   12. Mycology/fungal infections
   13. Parasitology/parasitic diseases
   14. Public health
   15. Quality improvement
   16. Transplant medicine
   17. Virology/viral diseases
   18. Antimicrobial agents

Opportunities exist for research outside of the ID Division: Yes

Program offers the opportunity to obtain a Master’s degree in a field such as Public Health, Education, Clinical Sciences, or Epidemiology (assuming appropriate arrangements are made): Yes