TRAINING PROGRAM DIRECTOR: Stephen A Spector, MD
RESEARCH INTEREST: HIV, CMV, microbial pathogenesis, host- pathogen interactions, genetics of disease, HIV- related clinical trials
DIVISION DIRECTOR OF INFECTIOUS DISEASES: George Liu, MD, PhD
RESEARCH INTEREST: Phase I through Phase IV clinical trials of antibacterials, antifungals, and non-HIV antivirals
TITLE(S) OF RECENT FELLOWS’ PUBLISHED PAPERS OR RESEARCH PROJECTS:
Campbell GR, Rawat P, Bruckman RS, Spector SA. Human Immunodeficiency Virus Type 1 Nef Inhibits Autophagy through Transcription Factor EB Sequestration. PLoS Pathog. 2015 Jun 26;11(6):e1005018. doi: 10.1371/journal.ppat.1005018. eCollection 2015 Jun. PubMed PMID: 26115100; PubMed Central PMCID: PMC4482621.
Campbell GR, Bruckman RS, Chu YL, Spector SA. Autophagy induction by histone deacetylase inhibitors inhibits HIV type 1. J Biol Chem. 2015 Feb 20;290(8):5028-40. doi: 10.1074/jbc.M114.605428. Epub 2014 Dec 24. PubMed PMID: 25540204; PubMed Central PMCID: PMC4335239.
Garg A, Rawat P, Spector SA. Interleukin 23 produced by myeloid dendritic cells contributes to T-cell dysfunction in HIV type 1 infection by inducing SOCS1 expression. J Infect Dis. 2015 Mar 1;211(5):755-68. doi: 10.1093/infdis/jiu523. Epub 2014 Sep 18. PubMed PMID: 25234720; PubMed Central PMCID: PMC4402373
Garg A, Spector SA. HIV type 1 gp120-induced expansion of myeloid derived suppressor cells is dependent on interleukin 6 and suppresses immunity. J Infect Dis. 2014 Feb 1;209(3):441-51. doi: 10.1093/infdis/jit469. Epub 2013 Sep 1. PubMed PMID: 23999600; PubMed Central PMCID: PMC3883171.
Andrade RM, Chaparro JD, Capparelli E, Reed SL. Auranofin is highly efficacious against Toxoplasma gondii in vitro and in an in vivo experimental model of actue toxoplasmosis. PLoS Negl Trop Dis. 2014 Jul 31;8(7):e2973. doi: 10.1371/journal.pntd.0002973. eCollection 2014.
Moodley A, Spector SA. Single high-dose vitamin D at birth corrects vitamin D deficiency in infants in Mexico. Int J Food Sci Nutr. 2015 May;66(3):336-41. doi:10.3109/09637486.2014.992006. Epub 2015 Jan 13. PubMed PMID: 25582182.
Moodley A, Qin M, Singh kk, Spector SA. Vitamin D related host genetic variants alter HIV disease progression in children. Int J Food Sci Nutr. 2015 May;66(3):336-41. doi: 10.3109/09637486.2014.992006. Epub 2015 Jan 13. PMID: 25582182
MAJOR FEATURES OF TRAINING PROGRAM:
The UCSD/RCHSD Pediatric Infectious Diseases Fellowship Program seeks to train highly-qualified physicians for teaching and research careers. Over a three year period, comprehensive instruction is provided in both clinical and laboratory disciplines. Clinical education emphasizes thorough development of skills and knowledge in pediatric infectious disease, including direct training in clinical microbiology and virology. Inpatient care experience is gained from a busy infectious disease consultative service provided to a tertiary-level Children’s Hospital and the University Medical Center. Outpatient care training is obtained in general pediatric ID, pediatric AIDS and pediatric TB clinics, as well as via phone consultations with community physicians. The detailed clinical component of this fellowship program ensures that graduates will be well-prepared to pass the Pediatric Infectious Diseases Board Certification Examination of the American Board of Pediatrics. Twenty-four months of the fellowship is protected time for development of skills in a selected area of microbial research and laboratory technology.
Rady Children’s Hospital San Diego
AVAILABLE FELLOWSHIP POSITIONS: Yearly
TRAINING FOR: MD, MD,PhD
FUNDING IS ENSURED FOR ALL 3 YEARS: YES
IS COMPLETION OF PEDIATRIC RESIDENCY TRAINING IN THE U.S. OR CANADA A REQUIREMENT? YES
THE PROGRAM OFFERS THE FOLLOWING TRAINING:
Program provides training in diagnostic microbiology using laboratories on site.
Program provides training in infection control and hospital epidemiology.
Program provides training in antimicrobial stewardship.
Program provides global health opportunities.
Program provides substantial experience for trainee in:
Opportunity to fulfill the ABP requirements for scholarly activity is available in the following general areas:
Documented liaison exists offering opportunities for research experience in the laboratory of investigator(s) who is/are not faculty of the section.
Program offers the opportunity to obtain a Master’s degree in a field such as Public Health, Education, Clinical Sciences or Epidemiology (assuming appropriate arrangements are made).
Graduate School courses are available to trainee (assuming appropriate arrangements are made).
Program includes ABP-required core curricula in scholarly activities in didactic lecture and or experiential courses for fellows (epidemiology, statistics, research design, quality improvement and academic careers).
The Infectious Diseases Service is the primary care provider for HIV infected children and adolescents.