UCLA Mattel Children’s Hospital

TRAINING PROGRAM DIRECTOR: Nava Yeganeh, MD
RESEARCH INTEREST: Prevention of Mother to Child Transmission of HIV; International Travel and International Adoption; The Care of the Immunocompromised Host

FELLOWSHIP COORDINATOR: Giovanna Alvarado

DIVISION DIRECTOR OF INFECTIOUS DISEASES: Grace Aldrovandi, MD
RESEARCH INTEREST: Microbiome’s role in the role of infant immune development; Breastfeeding and prevention of infection, including HIV

ASSOCIATE/DIVISION MEMBERS:

• James D Cherry, MD, MSc
  Research Interest: Pertussis; Vaccine Development and efficacy; Author of Feigen & Cherry Textbook of Pediatric Infectious Diseases
• Yvonne Bryson
  Research Interest: HIV CURE; Prevention of HIV Mother to Child Transmission
• Paul Krogstad
  Research Interest: Molecular virology and viral pathogenesis (enterovirus); Coccidioidmycosis; Osteomyelitis
• Jaime Deville
  Research Interest: Childhood vaccine development; Pediatric HIV treatment; Influenza treatment
• Karin Nielsen
  Research Interest: HIV Mother to Child Transmission; Cengenital Zika Infection; HIV in Adolescents
• Annabelle De St. Maurice
  Research Interest: Infection Control; Antimicrobial Stewardship; Epidemiology of outbreaks (Rift Valley, Seoul virus)
• Kristina Adachi
  Research Interest: Congenital Infections; Congenital Zika
• Omai Garner
  Research Interest: Microbiology and Laboratory Medicine; Point of Care Devices
• Deborah Lehman
  Research Interest: Medical Education; Congenital Infections

TITLE(S) OF RECENT FELLOWS’ PUBLISHED PAPERS OR RESEARCH PROJECTS:

• Baker AN, Bayer AM, Kolevic L, Najarro L, Viani RM, Deville JG.  Child, Caregiver, and Health Care Provider Perspectives and Experiences Regarding Disclosure of HIV Status to Perinatally Infected Children in Lima, Peru.  J Int Assoc Provid AIDS Care. 2018 Jan-Dec;17.
• Baker AN, Bayer AM, Viani RM, Kolevic L, Sim MS, Deville JG.  Morbidity and Mortality of a Cohort of Peruvian HIV-Infected Children 2003-2012.  Pediatr Infect Dis J. 2017 Dec 8.
• Bayer AM, Díaz CM, Chiappe M, Baker AN, Egoavil MS, Pérez-Lu JE, Gorbach PM, García PJ.  The odyssey of linking to and staying in HIV care among male sex workers in Peru.  J HIV AIDS. 2017 Jan;3(1).
• Tovar Padua L, Kamali A, Kim H, Green NM et al.  Unique Case of Disseminated Plague With Multifocal Osteomyelitis.  J Pediatric Infect Dis Soc. 2017 Sep 1;6(3):e165-e168
• Lugo D, Krogstad P.  Enteroviruses in the early 21st century: new manifestations and challenges.  Curr Opin Pediatr. 2016 Feb;28(1):107-13.
• Bristow CC, Adachi K, Nielsen-Saines K, Pilotto JH, Joao EC, Ank B, Morgado MG, Watts DH, Veloso VG, Klausner JD for the NICHD HPTN 040/ P1043 Team. Can the sample adequacy control (SAC) in Cepheid Xpert® CT/ NG assay predict infection? Journal of Microbiology and Experimentation. 2014;1(4): 00026.
• Adachi K, Klausner JD, Bristow CC, Xu J, Ank B, Morgado MG, Watts DH, Weir F, Persing D, Mofenson LM, Veloso VG,   Pilotto JH, Joao E, and Nielsen-Saines K for the NICHD HPTN 040 Study Team. Chlamydia and Gonorrhea in HIV-infected Pregnant Women and Infant HIV Transmission. Sexually Transmitted Diseases. 2015 Oct 42(10):554- 565. Epub 2015 August 27.
• Adachi K, Nielsen-Saines K, Klausner JD. Chlamydia trachomatis Infection in Pregnancy: The Global Challenge of Preventing Adverse Pregnancy and Neonatal Outcomes in Sub-Saharan Africa and Asia. WHO Special Issue on Maternal and Neonatal and Child Health Priorities for Asia and Africa. BioMed Research International. vol. 2016, Article ID 9315757, 21 pages, 2016. Epub 2016 April 7.
• Adachi K, Klausner JD Xu J, Ank B, Bristow CC, Morgado MG, Watts DH, Weir F, Persing D, PhD, Mofenson LM, Veloso VG,   Pilotto JH, Joao E, Gray G, Theron G, Santos B, Fonseca R, Kreitchmann R, Pinto J, Mussi-Pinhata M, Ceriotto M, Machado DM, Bryson YJ, MD, Grinsztejn B, Bastos FI, Siberry G, Nielsen-Saines K for the NICHD HPTN 040 Study Team. Chlamydia and gonorrhea in HIV-infected pregnant women and adverse infant outcomes. The Pediatric Infectious Disease Journal; 2016; 35(8):894-900. Epub 2016 May 9
• Adachi K, Xu J, Ank B, Watts DH, Mofenson LM, Pilotto JH, Joao E, Santos B, Fonseca R, Kreitchmann R, Pinto J, Mussi-Pinhata MM, Gray G, Theron G, Morgado MG, Bryson YJ, Veloso VG, Klausner JD, Moye J, Nielsen-Saines K; NICHD HPTN 040 Study Team.  Cytomegalovirus Urinary Shedding in HIV-infected Pregnant Women and Congenital Cytomegalovirus Infection.  Clinical Infectious Diseases. 2017 65;Aug 1:405-13; Epub 2017 Mar 22.
• Zin A, Tsui I, Rossetto J, Vasconcelos Z, Adachi K, Valderramos SG, Halai UA, Pone MVS, Pone SM, Silveira Filho JCB, Aibe MS, Costa ACC, Zin OA, Belfort Jr R, Brasil P, Nielsen-Saines K, Moreira MEL. Screening Criteria for Ophthalmic Manifestations of Congenital Zika Virus Infection. JAMA Pediatrics 2017 Sep 1;171(9):847-854. Epub 2017 July 17.
• Adachi K, Nielsen-Saines K. Zika Clinical Updates: Implications for Pediatrics. Current Opinion in Pediatrics. 2018; 30(1):105-116. doi: 10.1097/MOP.0000000000000582. Epub 2017 Nov 25. PubMed PMID: 29176498.
• Adachi K, Xu J, Yeganeh N et al.  Combined evaluation of sexually transmitted infections in HIV-infected pregnant women and infant HIV transmission. PLoS One. 2018 Jan 5;13(1) ): e0189851.
• Adachi K, Xu J, Ank B, Watts DH, Camarca M, Mofenson LM, Pilotto JH, Joao E, Gray G, Theron G, Santos B, Fonseca R, Kreitchmann R, Pinto J, Mussi-Pinhata MM, Machado DM, Ceriotto M, Morgado MG, Byrson YJ, Veloso VG, Grinsztejn B, Mirochnick M, Moye J,  Nielsen-Saines K for the NICHD HPTN 040 Study Team. Congenital CMV and Perinatal HIV. The Pediatric Infectious Disease Journal. Epub 2018 Mar 9.

GRANT FUNDING RECEIVED FOR FELLOW RESEARCH PROJECTS:

• Leidy Johana Tovar: UCLA CFAR/ AIDS Institute Seed Grant
• Kristina Adachi: Harry Winston Fellowship Award
• Santosh Nadipuram: Fogarty R24 Innovative technology seed grant
• Debbi Lugo: TRANSLATIONAL AIDS AND VIRAL PATHOGENESIS T32 AI089398
• Kevin Quinn: Friedman Fellowship Program; Myocarditis Foundation

MAJOR FEATURES OF TRAINING PROGRAM:

The UCLA Pediatric Infectious Diseases Fellowship Training Program is an ACGME approved 3-year program, dedicated to training fellows that excel clinically, are fully able to conduct successful independent research, and also act as outstanding medical educators.   In addition to seeing general pediatric infectious disease conditions including Kawasaki disease, complicated pneumonia, and osteomyelitis, fellows are trained to care of highly complicated patients including those in our pediatric intensive care unit, the cardiothoracic intensive care unit, and the neonatal intensive care unit. They also develop expertise in the care of immunocompromised patients as we collaborate closely with the various transplant services to care for the pediatric recipients of stem cell, renal, heart, liver, small bowel and multi-visceral transplants as well as offering gene therapy to SCID and CGD patients. Diverse research opportunities are available in basic and clinical sciences both at UCLA and at our global sites, and are chosen and tailored to meet the particular needs and interests of the individual fellow. Opportunities not only exist within the Division of Pediatric Infectious Diseases, but also throughout the entire UCLA Medical Campus. By the end of training, fellows will be conversant with the scientific method of approach to clinical and fundamental biological problems. Formal lectures, mentoring, and guidance prepare trainees for the preparation of grant proposals, abstracts, and manuscripts. Our fellows are fortunate to have the full resources and training modules of the UCLA Children’s Discover and Innovation Institute and the UCLA Clinical and Translation Sciences Institute including statistical support and grant writing workshops at their disposal during their training.

AFFILIATED HOSPITALS:

• Ronald Regan UCLA Medical Center
• Harbor-UCLA Medical Cneter
• Santa Monica-UCLA Medical Center
• Miller Children’s & Women’s Hospital Long Beach

AVAILABLE FELLOWSHIP POSITIONS: 1-2 yearly

Number of trainees completing program in the last 5 years: 8

TRAINING FOR:

• MD
• DO
• MD, PhD

FUNDING IS ENSURED FOR ALL 3 YEARS: Yes

VISAS ACCEPTED: J1

IS COMPLETION OF PEDIATRIC RESIDENCY TRAINING IN THE U.S. OR CANADA A REQUIREMENT?  YES

THE PROGRAM OFFERS THE FOLLOWING TRAINING:

Program provides training in diagnostic microbiology using laboratories on site.

Program provides training in infection control and hospital epidemiology.

Program provides training in antimicrobial stewardship.

Program provides global health opportunities.

Program provides substantial experience for trainee in:

• HIV
• Bone marrow transplantation
• Solid organ/transplantation
• Travelers/adoptees
• Adults
• Congenital immune deficiencies
• Public Health Clinics (TB, STI)

Opportunity to fulfill the ABP requirements for scholarly activity is available in the following general areas:

• Bacteriology/bacterial infections
• Epidemiology and statistics
• Infection control/hospital epidemiology
• Immunizations/Public health
• Mycology/fungal infections
• Parasitology/parasitic diseases
• Virology/viral diseases
• Antimicrobial agents/antimicrobial stewardship
• LA Department of Public Health

Documented liaison exists offering opportunities for research experience in the laboratory of investigator(s) who is/are not faculty of the section.

Program offers the opportunity to obtain a Master’s degree in a field such as Public Health, Education, Clinical Sciences or Epidemiology (assuming appropriate arrangements are made).

Graduate School courses are available to trainee (assuming appropriate arrangements are made).

Program includes ABP-required core curricula in scholarly activities in didactic lecture and or experiential courses for fellows (epidemiology, statistics, research design, quality improvement and academic careers.)

Program has an NIH-sponsored training grant.

The Infectious Diseases Service is the primary care provider for HIV infected children and adolescents.