Harbor-UCLA Medical Center

CHIEF OF INFECTIOUS DISEASES/TRAINING PROGRAM: Ken Zangwill, MD

RESEARCH INTERESTS: Infectious disease epidemiology and prevention, vaccine implementation, antimicrobial stewardship in the surgical setting, cost-burden/effectiveness studies of vaccine-related and other clinical topics, infection prevention and control, and development of rapid diagnostic tests for bacteremia. Other research opportunities for fellows are available in collaboration locally with the Division of Adult Infectious Diseases at Harbor-UCLA Medical Center (which includes national experts in endocarditis, fungal basic science and vaccine development, bacterial pathogenesis, and outcomes research) and elsewhere throughout the region.

ASSOCIATES:

• Michael Bolaris, MD
  Research Interests: Antimicrobial stewardship interventions, ambulatory care-based infection prevention and control, HIV clinical trials and HIV antiviral pharmacokinetic studies.
• Sylvia Yeh, MD
  Research Interests: Clinical evaluation, cost-effectiveness, and delivery of vaccine to at-risk community- and hospital-based populations. Survey studies of vaccine knowledge, attitudes, and practice. development and effectiveness.
• Chrisanna Mink, MD
  Research Interests:  Travel medicine, regulatory infectious diseases, clinical infectious diseases of international adoptees, clinical vaccine studies. Currently also acquiring a Master’s Degree in Health Journalism
• Brad Ackerson, MD
  Research Interests:  Clinical infectious diseases and vaccine research.
• Margie Keller, MD
  Research Interests: Pediatric HIV; magnetic resonance spectroscopy of cerebral metabolites in HIV; correlation of cerebral metabolites in HIV with age, treatment, neuropsychological evaluations; prevention of maternal transmission of HIV; pharmacokinetics and safety of antiretroviral medication; complications of HIV.
• Moon Lee, PhD
  Research Interests: General clinical virology
• Victor K. Wong, MD
  Research Interests:  Clinical infectious diseases.
• Jag Batra, MD
  Research Interests: HIV clinical trials, clinical infectious topics
• Tam Van, PhD
  Research Interests: Infectious diseases laboratory topics

TITLE(S) OF RECENT FELLOWS’ PUBLISHED PAPERS OR RESEARCH PROJECTS:

• Bizmark RS, et al. Impact of the 2007 change in antimicrobial prophylaxis guidelines on infectious endocarditis disease incidence in a nationally representative pediatric cohort. Am Heart J 2017;189:110-19.
• Nguyen DK, et al. Epidemiology of the clinical management of febrile infants <90 Days of age in the United States, 2002-2012. Pediatr Emerg Care, 2017; Sep 5. DOI: 10.1097/PEC.0000000000001262.
• Yeh SH, et al. Profile of the Pediatric Infectious Disease Workforce in 2015. J Pediatric Infect Dis Soc. 2017 Dec 22. doi: 10.1093/jpids/pix094.
• Daum RS, et al. A Placebo-Controlled Trial of Antibiotics for Smaller Skin Abscesses. N Engl J Med. 2017 Jun 29;376(26):2545-2555.
• Thompson GR 3rd, et al. Adjunctive Corticosteroid Therapy in the Treatment of Coccidioidal Meningitis. Clin Infect Dis. 2017 Jul 15;65(2):338-341.
• McKinnell JA, et al. Prevalence of and Factors Associated With Multidrug Resistant Organism (MDRO) Colonization in 3 Nursing Homes. Infect Control Hosp Epidemiol. 2016 Dec;37(12):1485-1488. Epub 2016 Sep 27.
• Bolaris MA, et al. Nevirapine Plasma Concentrations in Human Immunodeficiency Virus-Exposed Neonates Receiving High-Dose Nevirapine Prophylaxis as Part of 3-Drug Regimen. J Pediatric Infect Dis Soc. 2017 Mar 1;6(1):102-104.
• Gong CL, et al. The use of behavioral economics and social psychology to improve treatment of acute respiratory infections (BEARI): a cost-effectiveness analysis. J Gen Int Med, in press.
• Gong CL, et al. Management of asymptomatic term & late preterm newborns exposed to maternal intrapartum fever: A societal cost benefit analysis of the proposed “Triple I” algorithm. Pediatrics, in press.
• Nguyen DK, et al. Length of stay and complications associated with febrile infants <90 days of age hospitalized in the United States, 2000-2012. Hosp Pediatr, in press.

GRANT FUNDING RECEIVED FOR FELLOW RESEARCH PROJECTS:

Multiple sources related to research mentor. Most recently has included AHRQ, CDC, US Army, US Air Force, NIH-funded Clinical and Translational Science Institute at Harbor-UCLA, MAD-ID, UCLA Ctr for Health Sciences CTSI Laboratory Core.

MAJOR FEATURES OF TRAINING PROGRAM:

The goal of our three-year Fellowship program is to train competent ID specialists through a broad-based experience in research, teaching and clinical infectious diseases. Our southern California location provides tremendous exposure to a variety of immigrant and through-traveler populations enabling diverse clinical and research opportunities. We also send Fellows to local collaborating institutions for increased exposure to other more focused areas of infectious disease including academic/university-based hospitals and LA County Public Health.

AFFILIATED HOSPTALS:  Harbor-UCLA Medical Center, Miller Children’s Hospital, Mattel Children’s Hospital (UCLA), Children’s Hospital Los Angeles

NUMBER OF PEDIATRIC BEDS:  Ward 32, PICU 10, NICU 16, Nursery.

FELLOWS ACCEPTED EACH YEAR:  0-1

TRAINING FOR MD:  MD, MD PhD, DO.

FUNDING IS ENSURED FOR ALL 3 YEARS:   YES

VISAS ACCEPTED: J1

IS COMPLETION OF PEDIATRIC RESIDENCY TRAINING IN THE U.S. OR CANADA A REQUIREMENT?  YES

THE PROGRAM OFFERS THE FOLLOWING TRAINING:

Program provides training in diagnostic microbiology using laboratories on site:

• Microbiology Laboratory: YES
• Clinical Virus Isolation Laboratory:  YES
• Molecular Diagnostics:  YES

Program provides training control and hospital epidemiology  as:

• Didactic Lectures:  YES
• Hands on Experience: YES
• Infection Control Meetings/Membership: YES

Opportunity to flll the ABP requirements for schoarly activity is available in the following general areas:

• Bacteriology/Bacterial Infections:  YES
• Epidemiology and Statistics: YES
• Infection Control/Hospital Epidemiology:YES
• Immunizations/Public Health: YES
• Mycology/Fungal Infections:  YES
• Parasitology/Parasitic Diseases:  NO
• Antimicrobial Agents: YES

Research opportunities in the section’s program could be described as:

• Basic (bench):  YES
• Molecular: YES
• Translational: YES
• Epidemiologic: YES
• Clinical:  YES
• International/Public Health: Public Health only
• Health Services: YES
• HIV, Basic:  NO
• HIV, Clinical:  YES
• ACTG SITE:  YES

Documented liaison exists offering opportunities for research experience in the laboratory of investigator(s) who is (are) not faculty of the section: YES

Program offers the opportunity to obtain a Master’s degree in a field such as Public Health, Education, Clinical Sciences, or Epidemiology (assuming appropriate arrangements are made): NOT EXPLICITLY

Graduate school courses are available to trainee (assuming appropriate arrangements are made): YES

Program provides substantial clinical experiences for trainees in special areas/hosts.

• HIV:  YES
• Bone Marrow Transplantation:YES at off-site rotation (UCLA)
• Solid Organ/Transplantation:  YES at off-site rotation (UCLA)
• Travelers/Adoptees:  YES
• Adults:  YES, if desired  by the fellow
• Congenital Immune D eficiencies:  YES at off-site rotation (CHLA)

Program includes ABP-required core curricula in scholarly activities in didactc lecture course for fellows (includes epidemiology, statistics, research design, and academic careers):  YES

Program has an NIH-sponsored training grant: NO

The Infectious Diseases Service is the primary care provider for HIV-infected children and adolescents:  YES

Average Number of New Outpatient Consultations Per Month: 12

Average Number of New Outpatient Follow-Up Visits Per Month: 21

Average Number of New Inpatient Consultations Per Month:  18-20

Number of trainees completing program in the last 5 years:  3