University of California, San Francisco

TRAINING PROGRAM DIRECTOR: Theodore Ruel, MD

ASSOCIATE DIRECTOR/CO-DIRECTOR:  Manjiree Karandikar, MD, MBS

COORDINATOR: Catherine Le

CHIEF,  INFECTIOUS DISEASES: Theodore Ruel, MD

MAJOR FEATURES OF TRAINING PROGRAM:  This is three-year program geared to prepare fellows for careers in academic infectious diseases. The first year is focused on clinical training at the UCSF Benioff Children’s Hospital, including general and immunocompromised populations. In the second and third years, fellows complete clinical rotations in outpatient subspecialty clinics but devote the majority of time to research. For research mentorship, fellows can work within our division or with any of UCSF’s world-class researchers in the basic and clinical sciences.

TITLE(S) OF RECENT FELLOWS’ PUBLISHED PAPERS OR RESEARCH PROJECTS:

1. Andama A, Jaganath D*, Crowder R, Asege L, Nakaye M, Katumba D, Mukwatamundu J, Mwebe S, Semitala CF, Worodria W, Joloba M, Mohanty S, Somoskovi A, Cattamanchi A (Co-first author). The transition to Xpert MTB/RIF ultra: diagnostic accuracy for pulmonary tuberculosis in Kampala, Uganda. BMC Infect Dis. 2021 Jan 11;21(1):49
2. Jaganath D, Rajan J, Yoon C, Ravindran R, Andama A, Asege L, Mwebe SZ, Katende J, Nakaye M, Semitala FC, Khan IH, Cattamanchi A. Evaluation of multi-antigen serological screening for active tuberculosis among people living with HIV. PLoS One. 2020 Jun 4;15(6):e0234130
3. Wang C, Bauckman KA, Ross ASB, Symington JW, Ligon MM, Scholtes G, Kumar A, Chang HW, Twentyman J, Fashemi BE, Xavier RJ, Mysorekar IU (2019). A non-canonical autophagy-dependent role of ATG16L1 T300A variant in urothelial vesicular trafficking and uropathogenic Escherichia coli persistence. Autophagy. 15(3), 527-542.
4. Wilson, M.R., Sample, H.A., Zorn, K.C., Arevalo, S., Yu, G., Neuhaus, J., Federman, S., Stryke, D., Briggs, B., Langelier, C. and Berger, A., 2019. Clinical metagenomic sequencing for diagnosis of meningitis and encephalitis. New England Journal of Medicine, 380(24), pp.2327-2340.
5. Jenai Quan, Charles Langelier, Alison Kuchta, Joshua Batson, Noam Teyssier, Amy Lyden, Saharai Caldera, Aaron McGeever, Boris Dimitrov, Ryan King, Jordan Wilheim, Maxwell Murphy, Lara Pesce Ares, Katherine A Travisano, Rene Sit, Roberto Amato, Davis R Mumbengegwi, Jennifer L Smith, Adam Bennett, Roly Gosling, Peter M Mourani, Carolyn S Calfee, Norma F Neff, Eric D Chow, Peter S Kim, Bryan Greenhouse, Joseph L DeRisi, Emily D Crawford, FLASH: a next-generation CRISPR diagnostic for multiplexed detection of antimicrobial resistance sequences, Nucleic Acids Research, Volume 47, Issue 14, 22 August 2019, Page e83, https://doi.org/10.1093/nar/gkz418

GRANT FUNDING RECEIVED FOR FELLOW RESEARCH PROJECTS:

1. Clinical and Translational Science Institute TL1 Prescient Fellowship, 2020-2022
2. T32 NIH Training Grant 2019-2021
3. Pediatric Scientist Development Program Fellowship, 2018-2020
4. Clinical and Translational Science Institute TL1 Prescient Fellowship, 2017-2019
5. Thrashers Early Career Award, 2017-2019

AFFILIATED HOSPITALS:

UCSF Benioff Children’s Hospital, San Francisco: 183 beds

UCSF Benioff Children’s Hospital, Oakland: 191 beds

NUMBER OF INPATIENT/OUTPATIENT CONSULTS PER YEAR:  600

FELLOWS ACCEPTED EACH YEAR: 1

FUNDING ENSURED FOR ALL 3 YEARS: Yes

IS COMPLETION OF PEDIATRIC RESIDENCY TRAINING IN THE U.S. OR CANADA A REQUIREMENT? Yes

Program provides training (didactic lectures, hands on experience, or antimicrobial stewardship meetings/membership) in:

1. Microbiology lab on site
2. Infection control and hospital epidemiology
3. Antimicrobial stewardship
4. Immunocompromised hosts

Opportunities to fulfill the ABP requirements for scholarly activity is available in the following general areas:

1. 1. Antimicrobial agents
   2. Antimicrobial stewardship
   3. Bacteriology/bacterial infections
   4. Bioethics
   5. Clinical trials
   6. Epidemiology and statistics
   7. Global health
   8. HIV
   9. Immunizations
   10. Infection control/hospital epidemiology
   11. Medical education
   12. Mycology/fungal infections
   13. Parasitology/parasitic diseases
   14. Public health
   15. Quality improvement
   16. Transplant medicine
   17. Virology/viral diseases
   18. Antimicrobial agents

Opportunities exist for research outside of the ID Division: Yes

Program offers the opportunity to obtain a Master’s degree in a field such as Public Health, Education, Clinical Sciences, or Epidemiology (assuming appropriate arrangements are made): Yes